• Active against common bacterial eye pathogens, including Staphylococcus aureus and Staphylococcus
    epidermidis
    (including penicillin-resistant isolates), and some Streptococcus pneumoniae2
  • Contains ½ the concentration of dexamethasone compared to generic
    tobramycin/dexamethasone ophthalmic suspension formulations3
  • Power of an anti-inflammatory and anti-infective in each drop2
  • With the copay savings voucher most commercially insured patients will pay no more than $25*
*The rebate offer is not valid for patients who are enrolled in federal or state prescription benefit programs
Additional terms and conditions apply.
Click here for full prescribing information
Click here for the copay savings voucher

INDICATIONS AND USAGE
TOBRADEX® ST Suspension is a topical antibiotic and corticosteroid combination for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.
Dosage and Administration:
  • Instill one drop into the conjunctival sac(s) every 4 to 6 hours.
  • During the initial 24 to 48 hours, dosage may be increased to one drop every 2 hours.
  • Frequency should be decreased gradually as warranted by improvement in clinical signs, but care should be taken not to discontinue therapy prematurely.

IMPORTANT SAFETY INFORMATION

Contraindications:
  • TOBRADEX® ST Suspension, as with other ophthalmic corticosteroids, is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.
  • Hypersensitivity to any component of the medication.

Warnings and Precautions:
  • Intraocular pressure (IOP) increase – Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision. If this product is used for 10 days or longer, IOP should be monitored.
  • Sensitivity to topically applied aminoglycosides may occur.
  • Cataracts – Use of corticosteroids may result in posterior subcapsular cataract formation.
  • Delayed healing – The use of steroids after cataract surgery may delay healing and increase the incidence of bleb formation. In those diseases causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical steroids. The initial prescription and renewal of the medication order should be made by a physician only after examination of the patient with the aid of magnification such as slit lamp biomicroscopy and, where appropriate, fluorescein staining.
  • Bacterial infections – Prolonged use of corticosteroids may suppress the host response and thus increase the hazard of secondary ocular infections. In acute purulent conditions, steroids may mask infection or enhance existing infection. If signs and symptoms fail to improve after 2 days, the patient should be re-evaluated.
  • Viral infections – Employment of a corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution. Use of ocular steroids may prolong the course and may exacerbate the severity of many viral infections of the eye (including herpes simplex).
  • Fungal infections – Fungal infections of the cornea are particularly prone to develop coincidentally with long-term local steroid application. Fungus invasion must be considered in any persistent corneal ulceration where a steroid has been used or is in use.
  • If the product is used in combination with systemic aminoglycoside antibiotics, the patient should be monitored for total serum concentration of tobramycin.

Adverse Reactions:
Most common adverse reactions to topical ocular tobramycin are hypersensitivity and localized ocular toxicity, including eye pain, eyelid pruritus, eyelid edema, and conjunctival hyperemia. The reactions due to the steroid component are increases in intraocular pressure with possible development of glaucoma.

For additional information on TOBRADEX® ST Suspension, click here for the full prescribing information

References: 1. There is no FDA-approved therapeutic equivalent version of TOBRADEX® ST Suspension. Drugs@FDA entry for "Tobradex ST Suspension," available at http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Accessed December 5, 2011. 2. TOBRADEX® ST Suspension package insert. 3. Scoper SV, Kabat AG, Owen GR, et al. Ocular distribution, bactericidal activity and settling characteristics of TOBRADEX® ST ophthalmic suspension compared with TobraDex® ophthalmic suspension. Adv Ther. 2008;25(2):77-88.

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